After anlage of primary teeth at the beginning of the fifth month of embryogenesis some factors disturbed growth ability of dental plate behind the mentioned anlages. What serious consequence is possible?

Answer options

1. Permanent teeth won’t be anlaged
2. Dentin of primary teeth won’t be formed
3. Cervix of enamel organ won’t disintegrate
4. Formation of mouth vestibule will be disturbed
5. Formation of Hertwig’s epithelial root sheath will be disturbed