A patient complains of toothache. On examination he has been diagnosed with pulpitis. Which factor played a main pathogenic role in the development of pain syndrome in this case?

Answer options

1. Activation of one of the components of the complement system
2. Interleukin action
3. Inadequate stimulation of a mandibular nerve branch
4. Increased intratissular pressure in the dental pulp
5. Vasospasm