During an exacerbation of rheumatoid arthritis, the patient with a history of concomitant chronic gastritis was prescribed celecoxib. What decreases the digestive tract side effects of this drug?

Answer options

1. Predominant inhibition of cyclooxygenase-2
2. Predominant inhibition of cyclooxygenase-1
3. Phospholipase A2 inhibition
4. Predominant stimulation of adenylate cyclase
5. Phosphodiesterase inhibition