A patient diagnosed with acute pulpitis complains of toothache and swollen lower face on the side of the affected tooth. What is the leading mechanism of edema development in this disease?

Answer options

1. Disturbed microcirculation in the lesion focus
2. Disturbed nerve regulation of water metabolism
3. Disturbed trophic function of the nervous system
4. Increased aldosterone production
5. Hypoproteinemia