A woman with pheochromocytoma developed tachycardia, increased blood pressure, and sharp pain in the epigastric region after mental stress. What has caused the deterioration of the patient’s condition?

Answer options

1. Noradrenaline release by sympathetic nerves
2. Increased secretion of thyroid hormones
3. Activation of vegetative nuclei of the hypothalamus
4. Massive release of catecholamines by the adrenal glands
5. Increased synthesis of corticotropin