A child is languid, apathetic. Liver is enlarged and liver biopsy revealed a significant excess of glycogene. Glucose concentration in the blood stream is below normal. What is the cause of low glucose concentration?

Answer options

1. Deficit of a gene that is responsible for synthesis of glucose 1-phosphaturidine transferase
2. Low (absent) activity of glycogene phosphorylase in liver
3. Low (absent) activity of hexokinase
4. Low (absent) activity of glucose 6-phosphatase
5. High activity of glycogen synthetase