Vitamin B1 deficiency results in disturbance of oxidative decarboxylation of α-ketoglutaric acid. This will disturb synthesis of the following coenzyme:

Answer options

1. Nicotinamide adenine dinucleotide (NAD)
2. Coenzyme A
3. Thiamine pyrophosphate
4. Lipoic acid
5. Flavine adenine dinucleotide (FAD)

Explanation

Thiamine pyrophosphate (TPP), or thiamine diphosphate, is a thiamine (vitamin B1) derivative that is produced by the enzyme thiamine diphosphokinase. Thiamine pyrophosphate is a cofactor that is present in all living systems, in which it catalyzes several biochemical reactions. Thiamine pyrophosphate is synthesized in the cytosol and is required in the cytosol for the activity of transketolase and in the mitochondria for the activity of pyruvate-, oxoglutarate- and branched-chain keto acid dehydrogenases.