A patient had hemorrhagic stroke. Blood examination revealed strengthened kinin concentration.The patient was prescribed contrical. It was administered in order to inhibit the following proteinase:

Answer options

1. Pepsin
2. Trypsin
3. Collagenase
4. Chemotrypsin
5. Kallikrein

Explanation

The kallikrein system or simply kinin system is a poorly understood hormonal system with limited available research. It consists of blood proteins that play a role in inflammation, blood pressure control, coagulation, and pain. Its important mediators, bradykinin and kallidin are vasodilators and act on many cell types. Centrical is a kallikrein-protease inhibitor (KPI).