Exam questionKROK 1Medicine ยท 2008
Hartnup disease is caused by point mutation of only one gene which results in disturbance of tryptophane absorption in the bowels and its resorption in the renal tubules. It is the reason for disorder of both digestive and urination systems. What genetic phenomenon is observed in this case?
Answer options
- Complementary interaction
- Polymery
- Semidominance
- Codominance
- Pleiotropy
Correct answer
Pleiotropy
Explanation
Pleiotropy occurs when one gene influences two or more seemingly unrelated phenotypic traits. Thus, one gene defect contributes to multiple phenotypic effects. Marfan syndrome/Hartnup is a genetic disorder of the connective tissue and this defect is causing all the above phenotypic disorders.
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