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Exam questionKROK 1Medicine ยท 2008

A 30-year-old woman has applied a lipstick with a fluorescent substance for a long time. Then she got a limited erythema and slight peeling on her lip border, later there appeared transversal striae and cracks. Special methods of microscopic examination of the affected area helped to reveal sensibilized lymphocytes and macrophages in the connective tissue; cytolysis. What type of immunological hypersensitivity was developed?

Answer options

  1. I type (reaginic)
  2. Granulomatosis
  3. III type (immune complex cytotoxicity)
  4. IV type (cellular cytotoxicity)
  5. II type (antibody cytotoxicity)
Correct answer

IV type (cellular cytotoxicity)

Explanation

Type IV (cell-mediated, delayed, cellular cytotoxicity): antibody-independent T-cell mediated reactions e.g. positive Mantoux reaction (tuberculin test), Hashimoto's thyroiditis or transplant rejection, etc.

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