A 20-year-old patient complains of general weakness, dizziness, quick fatigability. Blood analysis results: Hb- 80 g/l. Microscopical examination results: erythrocytes are of modified form. This condition might be caused by:

Answer options

1. Obturative jaundice
2. Addison’s disease
3. Hepatocellular jaundice
4. Sickle-cell anemia
5. Acute intermittent porphyria

Explanation

A 20 year old patient complains of general weakness, dizziness, quick fatigability. Blood analysis results: Hb- 80 g/l. Microscopical examination results: erythrocytes are of modified form. This condition might be caused by:Sickle cell disease is a group of disorders that affects hemoglobin, the molecule in red blood cells that delivers oxygen to cells throughout the body. People with this disorder have atypical hemoglobin molecules called hemoglobin S, which can distort red blood cells into a sickle, or crescent, shape. It is also a point mutation and amino acid replacement in the beta chain of hemoglobin (substitution of glutamic acid with valine).