HomeKROK Question Archive
Exam questionKROK 1Medicine ยท 2008

As a result of posttranslative modifications some proteins taking part in blood coagulation, particularly prothrombin, become capable of calcium binding. The following vitamin takes part in this process:

Answer options

  1. C
  2. Bi
  3. B2
  4. A
  5. K
Correct answer

K

Explanation

Gamma-Carboxyglutamic acid is a calcium-binding amino acid and is required for the function of vitamin K-dependent proteins. In the blood coagulation cascade, vitamin K is required to introduce gamma-carboxylation of clotting factors II, VII, IX, X, and protein Z. In the biosynthesis of gamma-carboxyglutamic acid, the gamma -proton on glutamic acid is abstracted, and CO2 is subsequently added. This process is called carboxylation of glutamine acid.

This educational archive is provided by KROKEXAM and is not an official testing authority publication.