A 16-year-old boy after an illness has diminished function of protein synthesis in liver as a result of vitamin K deficiency. It will cause disturbance of:

Answer options

1. Osmotic blood pressure
2. Blood coagulation
3. Anticoagulant generation
4. Erythropoietin secretion
5. Erythrocyte sedimentation rate

Explanation

In the blood coagulation cascade, vitamin K is required to introduce gamma-carboxylation of clotting factors II, VII, IX, X, and protein Z. In the biosynthesis of gamma-carboxyglutamic acid, the gamma -proton on glutamic acid is abstracted, and CO2 is subsequently added. This process is called carboxylation of glutamine acid. Therefore, vitamin K deficiency may cause a disorder of blood coagulation.