Examination of a 35-year-old patient revealed high acidity of gastric juice. What receptors should be blocked in order to reduce it?

Answer options

1. (α-adrenoreceptors
2. a2-adrenoreceptors
3. α-adrenoreceptors
4. α-adrenoreceptors
5. Histamine

Explanation

There are three regulatory molecules that stimulate gastric juice secretion (acetylcholine, histamine, gastrin) and one regulatory molecule that inhibits its secretion (somatostatin). Acetylcholine is a neurotransmitter that is released by enteric neurons. Histamine is paracrine that is released from ECL (enterochromaffin-like) cells. Gastrin is a hormone that is released by G cells, endocrine cells that are located in the gastric epithelium. Somatostatin is also secreted by endocrine cells of the gastric epithelium; it can act as either a paracrine or a hormone.