Exam questionKROK 1Medicine ยท 2009
An oncological patient was administered methotrexate. With the lapse of time the target cells of the tumour lost sensitivity to this preparation. We can observe changes in the gene expression of the following enzyme:
Answer options
- Thiminase
- Dihydrofolate reductase
- Folate decarboxylase
- Folate oxidase
- Desaminase
Correct answer
Dihydrofolate reductase
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