Characteristic sign of glycogenosis is muscle pain during physical work. Blood examination reveals usually hypoglycemia. This pathology is caused by congenital deficiency of the following enzyme:

Answer options

1. Alpha amylase
2. Glycogen phosphorylase
3. Gamma amylase
4. Lysosomal glycosidase
5. Glucose 6-phosphate dehydrogenase

Explanation

Mcardle’s Disease is a congenital disease caused by a deficiency in glycogen phosphorylase in skeletal tissues. This phenomenon leads to muscle cramping during exertion. This deficiency causes hypoglycemia since glycogen cannot be converted back to glucose.