A patient has low rate of magnesium ions that are necessary for affixion of ribosomes to the endoplasmic reticulum. It is known that it causes disturbance of protein biosynthesis. At what stage is protein biosynthesis impaired?

Answer options

1. Termination
2. Replication
3. Translation
4. Amino acid activation
5. Transcription

Explanation

In eukaryotic cells, transcription occurs in the nucleus and translation takes place in the cytoplasm and the site of translation is on the rough (granular) endoplasmic reticulum aided by ribosomes. Therefore, preventing the attachment of ribosomes to the granular endoplasmic reticulum disturbs protein biosynthesis.