A cerebral trauma caused increased ammonia generation. What amino acid participates in the excretion of ammonia from the cerebral tissue?

Answer options

1. Glutamic
2. Tryptophan
3. Valine
4. Tyrosine
5. Lysine

Explanation

Ammonia intoxication occurs when blood ammonium rises because the capacity to detoxify it by the formation of glutamate and glutamine has been exceeded. Glutamine is an amide of glutamic acid which provides a non-toxic storage and transport form of ammonia. Ammonia increases the synthesis of glutamine in the brain. Accumulation of glutamine in the brain results in elevation of osmotic pressure in nervous cells leading to brain edema.