A 60-year-old male patient has a 9-year history of diabetes and takes insulin Semilente for the correction of hyperglycemia. 10 days ago he began taking anaprilin for hypertension. One hour after administration of the antihypertensive drug the patient developed hypoglycemic coma. What is the mechanism of hypoglycemia in case of anaprilin use?

Answer options

1. Decrease in glucose absorption
2. Increase of insulin Semilente half-life
3. Increase of bioavailability of insulin Semilente
4. Reduction of glucagon half-life
5. Inhibition of glycogenolysis

Explanation

Inhibition of glycogenolysis._ Anapirilin is a non-selective beta-blocker used both as an anti-arrhythmic, anti-angina, anti-hypertensive drug. One of the side effects is causing hypoglycemia in patients with insulin-dependent diabetes by inhibiting glycogenolysis.