Exam questionKROK 1Medicine ยท 2013
An 18-year-old male has been diagnosed with Marfan syndrome. Examination revealed a developmental disorder of connective tissue and eye lens structure, abnormalities of the cardiovascular system, arachnodactylia. What genetic phenomenon has caused the development of this disease?
Answer options
- Pleiotropy
- Incomplete dominance
- Codominance
- Complementarity
- Multiple allelism
Correct answer
Pleiotropy
Explanation
Marfan syndrome is a genetic disorder of connective tissue. Pleiotropy is when one gene influences 2 or more unrelated phenotypic traits. Basically, a multi-system affection caused by the mutation of one gene.
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