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Exam questionKROK 1Medicine ยท 2013

An 18-year-old male has been diagnosed with Marfan syndrome. Examination revealed a developmental disorder of connective tissue and eye lens structure, abnormalities of the cardiovascular system, arachnodactylia. What genetic phenomenon has caused the development of this disease?

Answer options

  1. Pleiotropy
  2. Incomplete dominance
  3. Codominance
  4. Complementarity
  5. Multiple allelism
Correct answer

Pleiotropy

Explanation

Marfan syndrome is a genetic disorder of connective tissue. Pleiotropy is when one gene influences 2 or more unrelated phenotypic traits. Basically, a multi-system affection caused by the mutation of one gene.

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