A patient has been admitted to the infectious diseases department for malaise, fever up to 38°C, jaundice. A few months ago, the patient underwent blood transfusion. The doctor suspected viral hepatitis B. What are the principal methods of laboratory diagnosis of hepatitis B?

Answer options

1. Detection of virions in blood by electron microscopy
2. Isolation of the virus in laboratory animals (neutralization reaction)
3. Isolation of the virus in chicken embryos
4. Virus isolation in cell culture and its identification by the cytopathic effects
5. Serological and gene diagnostics

Explanation

The gold standard of Hepatitis B Diagnosis is serology, which is checking Antibody Titre against the Antigens of the virus.