Children with Lesch-Nyhan syndrome have a severe form of hyperuri- cemia accompanied by the formation of tophi, urate calculi in the urinary tracts, as well as serious neuro-psychiatric disorders. The cause of this disease is the reduced activity of the following enzyme:

Answer options

1. Karbamoyl phosphate synthetase
2. Thymidylate synthase
3. Hypoxanthine-guanine phosphori-bosyltransferase
4. Dihydrofolate reductase
5. Xanthine oxidase

Explanation

Hypoxanthine-Guanine Phosphoribosyl Transferase.Lesch-Nyhan syndrome is caused by a deficiency of the enzyme HGPRT located on the X chromosome.