Diabetic nephropathy with uremia has developed in a patient with pancreatic diabetes. The velocity of glomerular filtration is 9 ml/min. What mechanism of a decrease in glomerular filtration velocity and chronic renal failure development is most likely in the case of this patient?

Answer options

1. Decrease in systemic arterial pressure
2. Reduction of active nephron mass
3. Arteriolar spasm
4. Tissue acidosis
5. Obstruction of nephron tubules with hyaline casts

Explanation

Diabetic nephropathy with uremia has developed in a patient with pancreatic diabetes. The velocity of glomerular filtration is 9 ml/min. What mechanism of a decrease in glomerular filtration velocity and chronic renal failure development is most likely in the case of this patient?Normal GFR is 90 – 120ml/min. Diabetic nephropathy damages kidney glomeruli, thereby reducing the number of nephrons that are supposed to filter uremia and waste.