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Exam questionKROK 1Medicine ยท 2014

A newborn baby has numerous hemorrhages. Blood coagulation tests reveal increased prothrombin time. The child is most likely to have a disorder of the following biochemical process:

Answer options

  1. Degradation of glutathione
  2. Conversion of methylmalonyl CoA to succinyl CoA
  3. Production of gamma-carboxyglutamate
  4. Hydroxylation of proline
  5. Conversion of homocysteine to methionine
Correct answer

Production of gamma-carboxyglutamate

Explanation

Gammacarboxyglutamate is an essential substrate in several proteins, including coagulation factors X, VII, IX, and XIV, vitamin K-dependent protein S and Z, prothrombin, transthyretin.

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