Exam questionKROK 1Medicine ยท 2014
A newborn baby has numerous hemorrhages. Blood coagulation tests reveal increased prothrombin time. The child is most likely to have a disorder of the following biochemical process:
Answer options
- Degradation of glutathione
- Conversion of methylmalonyl CoA to succinyl CoA
- Production of gamma-carboxyglutamate
- Hydroxylation of proline
- Conversion of homocysteine to methionine
Correct answer
Production of gamma-carboxyglutamate
Explanation
Gammacarboxyglutamate is an essential substrate in several proteins, including coagulation factors X, VII, IX, and XIV, vitamin K-dependent protein S and Z, prothrombin, transthyretin.
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