Exam questionKROK 1Medicine · 2014
In case of alkaptonuria, homogenti-sic acid is excreted in urine in large amounts. The development of this disease is associated with a disorder of metabolism of the following amino acid:
Answer options
- Asparagine
- Phenylalanine
- Alanine
- Tyrosine
- Methionine
Correct answer
Tyrosine
Explanation
In alkaptonuria, the enzyme (homogentisate 1,2- dioxygenase) is involved in the metabolism of phenylalanine and tyrosine. And also tyrosine is a product of phenylalanine. So, there’s excess tyrosine. So the RIGHT ANSWER IS "Tyrosine".
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