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Exam questionKROK 1Medicine · 2014

In case of alkaptonuria, homogenti-sic acid is excreted in urine in large amounts. The development of this disease is associated with a disorder of metabolism of the following amino acid:

Answer options

  1. Asparagine
  2. Phenylalanine
  3. Alanine
  4. Tyrosine
  5. Methionine
Correct answer

Tyrosine

Explanation

In alkaptonuria, the enzyme (homogentisate 1,2- dioxygenase) is involved in the metabolism of phenylalanine and tyrosine. And also tyrosine is a product of phenylalanine. So, there’s excess tyrosine. So the RIGHT ANSWER IS "Tyrosine".

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