Exam questionKROK 1Medicine · 2014
A male patient is 28 years old. Histological study of a cervical lymph node revealed a change of its pattern due to the proliferation of epithelioid, lymphoid cells and macrophages havi- ng nuclei in form of a horseshoe. In the center of some cell clusters there were non-structured light-pink areas with fragments of nuclei. What disease are these changes typical for?
Answer options
- Actinomycosis
- Syphilis
- Tumor metastasis
- Tuberculosis
- Hodgkin’s disease
Correct answer
Tuberculosis
Explanation
Pirogov-Langhans cells are formed by a fusion of epithelioid cells and are arranged in a horseshoe pattern, this is specific for granulomatous diseases e.g Tuberculosis, Sarcoidosis.
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