Steatosis is caused by the accumulation of triacylglycerols in hepatocytes. One of the mechanisms of this disease development is a decrease in the utilization of VLDL neutral fat. What lipotropics prevent the development of steatosis?

Answer options

1. Valine, B3, B2
2. Isoleucine, B1, B2
3. Alanine, B1, PP
4. Arginine, ^ B3
5. Methionine, B6, B12

Explanation

Steatosis occurs when the breakdown of fats in the liver is disrupted. Methionine, an essential amino acid, is a major lipotropic compound in humans. When estrogen levels are high, the body requires more methionine. Estrogens reduce bile flow through the liver and increase bile cholesterol levels. Methionine helps deactivate estrogens.