A 65-year-old man suddenly lost vision in one eye due to the retinal detachment. The patient underwent enucleation. Histological examination of the removed eye retina and choroid revealed clusters of atypical cells with marked polymorphism of cells and nuclei, with a moderate number of mitoses including the pathological ones. The cell cytoplasm and intercellular medium contained brown pigment resulting in positive DOPA reaction. Perls' reaction was negative. What is the most likely diagnosis?

Answer options

1. Pigmented mole
2. Cysticercosis
3. Melanoma
4. Hemorrhage
5. Wilson’s disease

Explanation

A 65-year-old male suddenly lost the vision in one eye due to the retinal detachment. The patient underwent enucleation. Histological examination of the removed eye retina and choroid revealed clusters of atypical cells with marked polymorphism of cells and nuclei, with a moderate number of mitoses including the pathological ones. The cell cytoplasm and intercellular medium contained brown pigment giving a positive DOPA reaction. Perls' reaction was negative. What is the most likely diagnosis? The Signs highlighted are typical for Melanoma.