After implantation of a cardiac valve a young man systematically takes indirect anticoagulants. His state was complicated by hemorrhage. What substance content has decreased in blood?

Answer options

1. Haptoglobin
2. Prothrombin
3. Heparin
4. Creatin
5. Ceruloplasmin

Explanation

Indirect Anticoagulants (e.g warfarin) act by inhibiting Prothrombin in the blood leading to decreased clotting of blood and increased bleeding time. Note that direct anticoagulants (e.g heparin) inhibit thrombin.