Characteristic sign of glycogenosis is muscle pain during physical work. Blood examination usually reveals hypoglycemia. This pathology is caused by congenital deficiency of the following enzyme:

Answer options

1. Glucose 6-phosphate dehydrogenase
2. γ-amylase
3. Lysosomal glycosidase
4. Glycogen phosphorylase
5. a-amylase

Explanation

Mcardle’s Disease is a congenital disease caused by a deficiency in glycogen phosphorylase in skeletal tissues. This phenomenon leads to muscle cramping during exertion. This deficiency causes hypoglycemia since glycogen cannot be converted back to glucose.