A 30-year-old patient's blood test has revealed the following: erythrocyte count is 6 × 1012/l, hemoglobin is 10,55 mmol/l. Vaquez's disease was diagnosed. Name the leading part of pathogenesis:

Answer options

1. B12-deficiency
2. Iron-deficiency
3. Hypoxia
4. Acidosis
5. Neoplastic erythroid hyperplasia

Explanation

Polycythemia Vera (VAQUEZ DISEASE) A myeloproliferative disorder of unknown etiology, characterized by abnormal proliferation of all hematopoietic bone marrow elements and an absolute increase in red cell mass and total blood volume, associated frequently with splenomegaly, leukocytosis, and