A 12-year-old child developed nephritic syndrome (proteinuria, hematuria, cyli-ndruria) 2 weeks after a case of tonsillitis, which is a sign of affected glomerular basement membrane in the kidneys. What mechanism is the most likely to cause the basement membrane damage?

Answer options

1. Granulomatous
2. Immune complex
3. Reaginic
4. Antibody-mediated
5. Cytotoxic

Explanation

A 12-year-old child has developed nephritic syndrome (proteinuria, hematuria, cylindruria) 2 weeks after the case of tonsillitis, which is a sign of affected glomerular basement membrane in the kidneys. What mechanism is the most likely to cause the basement membrane damage? Post streptococcal glomerulonephritis is characterized by the accumulation of immune complex (antibody-antigen) in the basement membrane leading to its damage.