Exam questionKROK 1Medicine ยท 2017
Exposure to colchicine resulted in metaphase plate of a human containing 23 chromosomes more than it is normal. Name this mutation:
Answer options
- Polyploidy
- Inversion
- Translocation
- Polyteny
- Aneuploidy
Correct answer
Polyploidy
Explanation
Colchicine promotes a change in chromosome structure without loss of sister chromatid cohesion in prometaphase, it is widely used to separate chromosomes at the metaphase and to induce polyploidy. Polyploid cells and organisms are those containing more than two paired (homologous) sets of chromosomes.
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