On autopsy of a 40-year-old woman, who had been suffering from rheumatoid arthritis, her liver is found to be dense and enlarged. On dissection its tissue is red-brown colored, with enlarged follicles resembling semi-transparent grayish-white granules. What is the most likely pathological process?

Answer options

1. Sugar-coated spleen
2. Splenic hyalinosis
3. Porphyry spleen
4. Sago spleen
5. Lardaceous spleen

Explanation

Sago spleen one with amyloid infiltration, the Malpighian corpuscles looking like grains of sand.Spleen. Amyloidosis of the spleen has two different anatomical patterns.Most commonly, the amyloid deposition is limited to the splenic follicles,resulting in the gross appearance of a moderately enlarged spleen dottedwith gray nodules (so-called "sago" spleen).Alternatively, the amyloid deposits may spare the follicles and mainlyinfiltrate the red pulp sinuses, producing a large, firm spleen mottled withwaxy discolorations ("lardaceous" spleen).