A patient with signs of emotional lability that result in troubled sleep has been prescribed nitrazepam. Specify the sleep-inducing mechanism of this drug:

Answer options

1. Blockade of opiate receptors
2. H1-histamine receptors stimulation
3. Supression of serotonergic neurotransmission
4. Inhibition of stimulating amino acids
5. GABA-ergic system activation

Explanation

nitrazepam act on benzodiazepine receptors in the brain which are associated with the GABA receptors, causing an enhanced binding of GABA to GABA receptors.