A woman with polyarticular rheumatoid arthritis was prescribed a non-steroidal antiinflammatory drug - diclofenac sodium. After the patient has been taking it for some time, her concomitant disease exacerbated, which forced the doctor to cancel the prescription of this drug. What concomitant disease could necessitate cancellation of this drug prescription?

Answer options

1. Essential hypertension
2. Diabetes mellitus
3. Bronchial asthma
4. Ischemic heart disease
5. Ulcer disease

Explanation

A non-steroidal anti-inflammatory drug Diclofenac is a potent inhibitor of prostaglandin, prostaglandins protect the gastric mucosa against the erosive action of ulcerogenic drugs, but in this case, any drug that can inhibit prostaglandin will be causing ulcer.Examples of NSAIDs include