Regional lymph nodes surrounding an infected wound are enlarged. Histological examination shows increased number of macrophages, lymphocytes, and lymphatic follicles in the cortical layer of the lymph nodes, as well as a large amount of plasma cells. What process in the lymph nodes is indicated by these histological changes?

Answer options

1. Antigen stimulation
2. Neoplastic aberration
3. Congenital deficiency of lymphoid tissue
4. Transplant rejection
5. Acquired deficiency of lymphoid tissue

Explanation

Antigen stimulation: formation of specific antibody from plasma cells and specifically activated t- lymphocytes against an antigen, with help of antigen-presenting cells (macrophages and monocytes).