In case of inflammation, local anesthetic effect of Novocaine decreases in strength. What process in the inflammation focus leads to disturbed hydrolysis of novocaine salt and therefore disturbed release of active anaesthetic base?

Answer options

1. Activation of succinate dehydrogenase
2. Local tissue acidosis
3. Local tissue alkalosis
4. Inhibition of oxidative phosphorylation
5. Inhibition of carbonic anhydrase

Explanation

In case of inflammation, local anesthetic effect of Novocaine decreases in strength. What process in the inflammation focus leads to disturbed hydrolysis of novocaine salt and therefore disturbed release of active anaesthetic base?Esters are not active at acidis PH. Esters - Novocaine and tetracaine (Procaine) Lidocaine (Xycaine) is amide