A lab rat has subcutaneously received mercury(II) chloride in the amount of S mykg: 24 hours later the plasma creatinine concentration increased several times. What mechanism of retention azotemia is observed in this case?

Answer options

1. Increased creatinine production in the muscles
2. Increased creatinine secretion in the renal tubules
3. Increased creatinine reabsorption
4. Decreased glomerular filtration
5. Increased glomerular filtration

Explanation

Mercury chloride causes acute renal failure, by decreasing blood supply to the kidneys. Because of this glomerular filtration decreases. Since filtration is decreased, creatine is not excreted and the level of creatine increases in blood.