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Exam questionKROK 1Medicine ยท 2020

A researcher is investigating the relationship between inflammatory mediators. He performs an experiment, investigating the effect of nonsteroidal anti-inflammatory drugs (NSAIDs) on patients with high-grade fever. HIS research indicates that certain NSAIDs act as competitively reversible inhibitors of the cyclooxygenase (COX) enzymes. It is known that COX catalyzes the formation of prostaglandins from a certain molecule that itself is derived from the cellular phospholipid bilayer by phospholipase A2. Which of the following molecules is a precursor of an inflammatory mediators mentioned above?

Answer options

  1. Tyrosine
  2. Cholesterol
  3. Palmitic acid
  4. Proopiomelanocortin
  5. Arachidonic acid
Correct answer

Arachidonic acid

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