In a patient with hyperthyroidism, the intensity of energy metabolism is increased. However, the patient complains of decreased physical strength and low working ability Why are these signs observed?

Answer options

1. Heart failure
2. Accumulation of end products of metabolism in muscles
3. Increased levels of ADP and H3P04
4. Separation of biological oxidation and oxidative phosphorylation
5. Increase AMP levels in muscles