47 y.o. patient complains of intensive skin itching, jaundice, bone pain. The skin is hyperpigmentated. There are multiple xanthelasma palpebrae. The liver is 6 cm enlarged, solid with acute edge. The blood analysis revealed total bilirubin -160 mkmol/L, direct -110 mkmol/L, AST- 2.1 mmol/L, ALT- 1,8 mmol/L, alkaline phosphotase - 4,6 mmol/L, cholesterol- 9.2 mmol/L, antimitochondrial antibodies M2 in a high titer. What is the probable diagnosis?