A 54 y.o. patient has been suffering from osteomyelitis of femoral bone for over 20 years. In the last month there appeared and gradually progressed edemata of lower extremities. Urine analysis: proteinuria - 6,6 g/L. Blood analysis: disproteinemia in form of hypoalbuminemia, increase of α2- and γ-globulins, ESR - 50 mm/h. What is the most probable diagnosis?

Answer options

1. Systemic lupus erythematosus
2. Acute glomerulonephritis
3. Myelomatosis
4. Chronic glomerulonephritis
5. Secondary renal amyloidosis

Explanation

A 54 y.o. patient has been suffering from osteomyelitis of femoral bone for over 20 years. In the last month there appeared and gradually progressed edemata of lower extremities. Urine analysis: proteinuria - 6,6 g/L. Blood analysis: disproteinemia in form of hypoalbuminemia, increase of ?2- and ?-globulins, ESR- 50 mm/h. What is the most probable diagnosis?The patient has a history of chronic disease and in a urine increase level of protein and increase of ?2- and ?-globulins. One common sign of kidney amyloidosis is the presence of abnormally high levels of protein in the urine, a condition known as proteinuria. Healthy kidneys prevent protein from entering the urine, so the presence of protein may be a sign that the kidneys aren't working properly.