A 65 y.o. man who has problems with urination as a result of benign prostate gland adenoma dveloped fever and chill, hypotension, sinus tachycardia. Skin is warm and dry. Clinical blood analysis revealed absolute granulocytopenia. These hemodynamic changes are most likely to be caused by:

Answer options

1. Secondary reflex vasodilatation as a result of lowered cardiac output
2. Secondary endothelial changes as a result of bacterial lesion
3. Endotoxemia with activation of complement system
4. Reflex vagus stimulation with lowered cardiac output
5. Secondary circulation insufficiency with retained systolic function as a result of peripheral vasoconstriction