A 54 y.o. woman has been ill with osteomyelitis of femoral bone for over 20 years. During the last month there appeared and have been steadily increasing edemata of lower extremities. Urine analysis revealed: proteinuria - 6,6 g/l. Blood analysis: disproteinemia in form of hypoalbuminemia, raise of a2- and 7-globulines, ESR - 50 mm/h. What is the most probable diagnosis?

Answer options

1. Secondary renal amyloidosis
2. Acute glomerulonephritis
3. Chronic glomerulonephritis
4. Myelomatosis
5. Systematic lupus erythematosus

Explanation

A 54 y.o. woman has been ill with osteomyelitis of femoral bone for over 20 years. During the last month there appeared and have been steadily increasing edemata of lower extremities. Urine analysis revealed: proteinuria - 6,6 g/l. Blood analysis: disproteinemia in form of hypoalbuminemia, raise of a2- and 7-globulines, ESR- 50 mm/h. What is the most probable diagnosis? The patient has a history of chronic disease( osteomyelitis of femoral bone) and in a urine increase level of protein and increase of ?2- and ?-globulins. One common sign of kidney amyloidosis is the presence of abnormally high levels of protein in the urine, a condition known as proteinuria. Healthy kidneys prevent protein from entering the urine, so the presence of protein may be a sign that the kidneys aren't working properly.