A 41 y.o. woman complains of weakness, fatigue, fever up to 38°C, rash on the face skin, pain in the wrists and the elbows. On physical examination: erythematous rash on the cheeks with "butterfly"look, the wrists and elbow joints are involved symmetrically, swollen, sensitive, friction rub over the lungs, the heart sounds are weak, regular, HR-88/min, BP- 160/95 mm Hg. Hematology shows anemia, leucopenia, lymphopenia; on urinalysis: proteinuria, leukocyturia, casts. What is the main mechanism of disease development?

Answer options

1. Production of antimitochondrial antibodies
2. Production of myocytes antibodies
3. Production of antibodies to doublestranded DNA
4. Production of myosin antibodies
5. Production of antibodies to endothelial cells

Explanation

A 41 y.o. woman complains of weakness, fatigue, fever up to 380C, rash on the face skin, pain in the wrists and the elbows. On physical examination: erythematous rash on the cheeks with "butterfly"look, the wrists and elbow joints are involved symmetrically, swollen, sensitive, friction rub over the lungs, the heart sounds are weak, regular, HR- 88/min, BP- 160/95 mm Hg. Hematology shows anemia, leucopenia, lymphopenia; on urinalysis: proteinuria, leukocyturia, casts. What is the main mechanism of disease development?Is an autoimmune systemic disease in which the body's immune system mistakenly attacks healthy tissue in many parts of the body.American College of Rheumatology (ACR) established. A person has SLE if any four out of eleven symptoms are present simultaneously or serially on two separate occasions. • Malar rash (rash on cheeks- BUTTERFLY RASH) • Discoid rash (red, scaly patches on the skin that cause scarring). • Serositis: