A 50-year-old patient has been admitted to the clinics with atrophic gastritis. Blood count: erythrocytes -3,8 × 1012/l, Hb - 68 g/l, c.i. - 1, macroanisocytosis, poikilocytosis. There is megaloblastic type of haemopoesis. A number of leukocytes, reticulocytes and thrombocytes is lreduced. Which pathology is suspected?

Answer options

1. Irondeficiency anemia
2. Thalassaemia
3. Hemolytic anemia
4. B12-deficiency anemia
5. Post-hemorrhagic anemia

Explanation

A 50 year old patient has been admitted to the clinics with atrophic gastritis. Blood count: erythrocytes -3,8 • 1012/l, Hb - 68 g/l, c.i. - 1, macroanisocytosis, poikilocytosis. There is megaloblastic type of haemopoesis. A number of leukocytes, reticulocytes and thrombocytes is lreduced. Which pathology is suspected? Vitamin B12 deficiency anemia is a low red blood cell count due to a lack (deficiency) of vitamin B12. Vitamin B12 deficiency leads to Macrocytic, megaloblastic anemia; hypersegmentation PMNs; paresthesias, and subacute combined degeneration(degeneration of dorsal column, lateral corticospinal tract, and spinocerebellar tracts) due to abnormal myelin. Prolonged deficiency leads to irreversible nerve damage. Pernicious anemia is the most common cause of vitamin B12 deficiency.antibody to gastric parietal cell leads to the ineffective secretion of intrinsic factor (IF)leads to vitamin B12 deficiency due to decreased uptake in the terminal ileum. decrease uptake in the accompanied by achlorhydria and atrophic gastritisatrophic gastritis increases the risk of gastric cancer.