A 16-year-old boy was admitted to the hospital for the reason of intractable nasal hemorrhage and intolerable pain in the right cubital articulation. Objectively: the affected articulation is enlarged and exhibits defiguration and skin hyperaemia. There are manifestations of arthropathy in the other articulations. Ps- 90 bpm; colour index - 1,0, WBC - 5,6 × 109/l, thrombocytes- 220 × 109/l, ESR - 6 mm/h. Lee-White coagulation time: start - 24', finish - 2710" What drug will be the most effective for this patient treatment?