An infant is 2 days old. He was born full-term with signs of intrauterine infection, and therefore receives antibiotics. Neonates should be given antibiotics at longer intervals and lower doses compared to older children and adults because:

Answer options

1. Neonates have higher hematocrit
2. Neonates have lower concentration of protein and albumin in blood
3. Neonates have a decreased blood pH
4. Neonates have a reduced activity of glucuronyl transferase
5. Neonates have lower glomerular filtration