A 16-year-old adolescent has been hospitalized with complaints of unceasing nasal hemorrhage and unbearable pain in his right elbow joint. Objectively: the large joint is enlarged and defigurated, the skin over the joint is hyperemic. Arthropathy signs can be observed in the other joints. Ps- 90/min. Blood test: erythrocytes - 3,9 × 1012/l, Hb-130 g/l, color index - 1,0, leukocytes - 5,6 × 109/l, platelets - 220 × 109/l, ESR - 6 mm/hour. Lee-White coagulation time: start- 24', end- 27'10". What drug would be most efficient in the treatment of this patient?